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In the games I play now, debuffs do not stack generally, it's a basic concept of gameplay because of the way players consistently break things when they do. However, one might have them stack to a limit, such as Regen status in Ashes Alpha-1. A limit of 2 or 3 would allow two of the same Archetype who happen to be in a party, boss raid, or just friends trying to do stuff, to not be in a situation where they go for the same debuff and make each other less effective or efficient.
But the perspective I was reading your post from, made me think you meant 'only one debuff can be applied at a time', given the strength of them, this seemed like a plausible thing, and I've also seen games where there is a limit to 'debuffs that a single player of X class can apply to a target' I.e. the character must choose X number of their debuffs, apply those, and cannot apply more.
This is admittedly not the usual term for 'stacking', but different people use different terms, so I requested the clarification, and should have done so better (with all this post).